Hydroxypropyl Betadex destroys the intramolecular hydrogen bond by hydroxypropylation of β - CD, so that the water solubility of Hydroxypropyl Betadex is significantly improved, so that the solubility of insoluble drugs is significantly improved.
Generally, high concentration of drugs in eye drops is required, and some drugs have certain irritation. Therefore, the eye tissue is very easy to produce irritation, which is a common disadvantage of eye drug delivery preparations.
Hydroxypropyl Betadex can reduce the eye irritation of ophthalmic preparations in the following ways:
①mask the irritation through the inclusion of stimulant drugs.
②Replace the excipients that are irritating to the eye tissue.
③By increasing the corneal transmittance of the drug, improving the bioavailability of the drug, reducing the concentration of the drug, and reducing the stimulation of the high concentration drug.
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