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5-Bromopyrimidine (CAS: 4595-59-9): A Key Intermediate for Pharmaceutical and Agrochemical Synthesis | |
5-Bromopyrimidine (CAS Number: 4595-59-9) is a halogenated heterocyclic compound that serves as a valuable intermediate in the synthesis of pharmaceuticals, agrochemicals, and advanced materials. As a brominated derivative of pyrimidine, it offers high reactivity at the 5-position, making it a preferred substrate for metal-catalyzed cross-coupling reactions such as Suzuki, Heck, and Buchwald–Hartwig. Basic Information Chemical Name: 5-Bromopyrimidine CAS Number: 4595-59-9 Molecular Formula: C4H3BrN2 Molecular Weight: 158.98 g/mol Appearance: off-white crystal powder Purity: ≥98% (GC or HPLC) Applications 5-Bromopyrimidine is widely used in the preparation of: Pharmaceutical APIs – as a key intermediate in antiviral, anticancer, and kinase inhibitor compounds. Agrochemicals – for the synthesis of herbicidal and fungicidal actives. Advanced materials – as a precursor for functionalized pyrimidine-based ligands and bioactive heterocycles. Due to the electron-deficient nature of the pyrimidine ring, the bromine atom at position 5 readily undergoes substitution or palladium-catalyzed coupling, enabling the construction of diverse molecular scaffolds. Market & Supply As demand for nitrogen-containing heterocycles continues to grow in pharmaceutical R&D, 5-Bromopyrimidine has gained increasing importance. UCHEM supplies high-purity 5-Bromopyrimidine with full documentation (COA, MSDS, NMR) and supports global delivery. We also supply the following products： 2-Chloropyrimidine CAS:1722-12-9 2-Bromopyrimidine CAS:4595-60-2 2-Cyanopyrimidine CAS:14080-23-0 Contact Us For bulk inquiries, technical specifications, or sample requests of 5-Bromopyrimidine (CAS 4595-59-9), please contact UCHEM at www.myuchem.com or email uchemsales@gmail.com. | |
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2025-07-27 (0.579 sec)