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5'-O-DMT-N4-Bz-5-Me-dC (CAS 104579-03-5) Properties and Applications | |
5'-O-DMT-N4-Bz-5-Me-dC CAS:104579-03-5 is a specially modified nucleoside derivative with significant value in nucleic acid chemistry and biological research. Its structure includes three essential modifications: 5-Methylcytosine: Enhances epigenetic stability and improves resistance to enzymatic degradation, making it fundamental for studying DNA methylation and gene regulation. N4-Benzoyl protection: Prevents unwanted side reactions during solid-phase phosphoramidite synthesis, ensuring high selectivity and purity in nucleotide coupling. 5'-O-Dimethoxytrityl (DMTr) group: An acid-labile protecting group that facilitates efficient deprotection and purification during automated DNA synthesis. Applications Oligonucleotide synthesis: Serves as a key intermediate for preparing oligonucleotides containing methylcytosine, widely used in gene regulation, epigenetics, and nucleic acid drug development. Nucleic acid research tools: Improves stability and binding specificity of DNA fragments, making it valuable for probe design and molecular biology studies. Biopharmaceutical research: As a modified monomer, it supports the preparation of DNA molecules with enhanced properties, laying the foundation for antisense oligonucleotides, siRNA, and novel nucleic acid therapeutics. Material and connector applications: Its structural characteristics also enable potential use in optical devices and bio-conjugation. In summary, 5'-O-DMT-N4-Bz-5-Me-dC (CAS: 104579-03-5) is not only a critical building block for efficient DNA synthesis but also a key compound bridging basic research and applied development. | |
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| Target State: All States Target City : All Cities Last Update : 04 September 2025 3:48 PM Number of Views: 43 | Item Owner : Nina He Contact Email: Send email to item owner Contact Phone: (None) |
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2025-09-08 (0.578 sec)