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2,2-Difluorobenzodioxole-4-carboxaldehyde (CAS 119895-68-0) - Fluorinated Aromatic Building Block


2,2-Difluorobenzodioxole-4-carboxaldehyde (CAS: 119895-68-0) is a high-value fluorinated aromatic compound widely recognized for its importance in pharmaceutical, agrochemical, and specialty chemical research. As a highly functionalized benzodioxole derivative, it offers excellent reactivity, structural rigidity, and stability, making it an ideal building block for advanced organic synthesis.

This compound appears as a stable, high-purity solid and is frequently selected by R&D laboratories and chemical manufacturers for its reliability and versatility in multi-step synthesis. Its difluoro-substituted aromatic ring plays a crucial role in enhancing bioavailability, metabolic stability, and binding affinity in lead-compound optimization, making it particularly valuable for medicinal chemistry applications.

Key Applications
1. Medicinal & Pharmaceutical Chemistry
2,2-Difluorobenzodioxole-4-carboxaldehyde serves as an essential intermediate for designing novel drug candidates. The difluoro-functional group is known to improve lipophilicity and metabolic resistance, making this compound a preferred building block in the development of CNS drugs, anti-infectives, and small-molecule inhibitors.

2. Chemical Synthesis
Owing to its versatile aldehyde functionality, it is widely used as a starting material for condensation reactions, oxidative transformations, and heterocycle construction. It enables the synthesis of structurally complex organic molecules with precise fluorinated features.

3. Biological Research
The compound is employed as a probe for studying enzyme-catalyzed reactions and biological pathways. Its fluorinated aromatic ring provides unique spectroscopic and biochemical behavior, aiding researchers in understanding molecular interactions within biological systems.

4. Agrochemical Development
Due to its strong stability and electron-withdrawing fluorine atoms, 2,2-Difluorobenzodioxole-4-carboxaldehyde is frequently used as a precursor in synthesizing crop-protection agents, herbicides, and plant growth regulators.

5. Specialty Chemical Manufacturing
It is utilized in the production of high-performance materials and fine chemicals that require precise aromatic fluorination, contributing to improved durability, reactivity, and thermal performance.

We are committed to providing superior-quality fluorinated intermediates to support innovation in pharmaceuticals, agrochemicals, and advanced material development. Contact us for quotations, samples, or further technical support.

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Last Update : 27 November 2025 2:32 PM
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Item  Owner  : Nina He
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